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大量
- 供应商：
Alpha Med Science（Panasonic）
- 保修期：
1年
科研产品，不能用于临床
MED64平面微电极阵列记录系统是日本Alpha Med Science公司生产的完整易用的多通道离体胞外神经电生理研究工具。系统包括了离体电生理研究所需的一整套硬件设备耗材和分析软件。使用者可以方便快捷的对离体材料如脑片、心肌切片、培养的神经细胞或心肌细胞、干细胞等材料进行电生理检测；被试细胞或组织直接在电极涂层物质上培养，可以允许测量到细胞外直接相邻的局部电变化，同时并行记录多个细胞的电生理信号。MED64设备可以同时记录和刺激不同位点；而且，MED64记录还是非侵入式的，因此不会损伤细胞，这个特性使其适用于在同一个培养样本上进行长时程记录和重复记录，因而允许监视培养物对药物刺激的响应的较长时间的演变。结合光学记录方法，可以实现光电联合检测。
| MED64是以下研究的理想工具：
● 诱发性活动（fEPSPs）
● 自发性活动（spiking）
● 生物节律研究
● 突触可塑性（LTP/LTD），学习，记忆
● 心脏研究（起搏特性和电兴奋传导特性）
● 干细胞研究
● 安全药理学（如CNS毒性和QT间期延长）
● 急性脑片进行药物测试（癫痫，阿尔茨海默氏症，疼痛，肥胖症，厌食症，心律失常等等）
● 培养细胞或者脑片进行慢性药物测试
● iPS / ES细胞来源的心肌细胞QT延长筛查 |  |
MED64的特点：
·整合了放大器/刺激器、连接器、电极和软件－来源于Panasonic “Technics” Hi-Fi音响技术－可靠而且简单的铂黑微电极阵列，是目前市场上噪音最小的电极。
·阻抗，低噪声，高性噪比
·同一时间获取64个位点的电生理信号
·适用于神经组织切片、组织培养、细胞培养等离体样本
·唯一可在湿度培养箱持续记录的微电极阵列记录系统
·适合电信号空间和时间关系等网路电生理研究电生理记录与细胞形态研究可同步进行
MED64 已经成功应用于：
- 中枢神经系统：如大脑皮层、海马体、视网膜、视交叉上核、杏仁核；
- 周围神经系统：如背根神经节
- 心肌 （心房、心室、心肌细胞）和其它易兴奋组织（如平滑肌）
- 急性脑切片, 切片外植体和分离培养物
用户推荐书
- Prof. Gary Lynch, University of California at Irvine The MED system makes it possible for you to do at last, stimulation from different places within the brain tissue, in a much more naturalistic pattern…, rather than a point source stimulation which is very un-physiological…We have been able to look at drug effects… over dozens, even hundreds of neurons simultaneously
- Ole Paulsen, M.D., Ph.D., University Department of Pharmacology, Oxford, U.K A major challenge of modern neuroscience is to understand how neurons operate together in a network. .. (MED) offers an exciting opportunity to study mechanisms underlying network activity
香港伯齐科技（Bio-Gene）为MED64平面微电极矩阵记录系统在中国大陆和香港的独家代理商。
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
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文献和实验Age-related cognitive impairment: Role of reduced synaptobrevin-2 levels in memory and synaptic plasticity deficits.
Orock A, Logan S, Deak F.
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Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects.
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New role of P2X7 receptor in an Alzheimer’s disease mouse model
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Mol Psychiatry. 2018 Jun 22. doi: 10.1038.
Inhibition of non-NMDA ionotropic glutamate receptors delays the retinal degeneration in rd10 mouse.
Xiang Z, Bao Y, Zhang J, Liu C, Xu D, Liu F, Chen H, He L, Ramakrishna S, Zhang Z, Vardi N, Xu Y.
Neuropharmacology. 2018 Sep 1;139:137-149.
Electrophysiological characteristics of hippocampal postnatal early development mediated by AMPA receptors in rats.
Chen XY, Zhang AF, Zhao W, Gao YD, Duan HM, Hao P, Yang ZY, Li XG.
Cheng Li Xue Bao. 2018 Apr 25;70(2):106-114.
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease.
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Cell Rep. 2018 Jul 17;24(3):713-723.
A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer’s Disease.
Wang X, Liu D, Huang HZ, Wang ZH, Hou TY, Yang X, Pang P, Wei N, Zhou YF, Dupras MJ, Calon F, Wang YT, Man HY, Chen JG, Wang JZ, Hébert SS, Lu Y, Zhu LQ.
Biol Psychiatry. 2018 Mar 1;83(5):395-405.
Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease.
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Memantine improves outcomes after repetitive traumatic brain injury.
Mei Z, Qiu J, Alcon S, Hashim J, Rotenberg A, Sun Y, Meehan WP 3rd, Mannix R.
Behav Brain Res. 2018 Mar 15;340:195-204.
Adenosine has two faces: Regionally dichotomous adenosine tone in a model of epilepsy with comorbid sleep disorders.
Warren TJ, Simeone TA, Smith DD, Grove R, Adamec J, Samson KK, Roundtree HM, Madhavan D, Simeone KA.
Neurobiol Dis. 2018 Feb 27;114:45-52.
Increased GSNOR Expression during Aging Impairs Cognitive Function and Decreases S-Nitrosation of CaMKIIα.
Zhang Y, Wu K, Su W, Zhang DF, Wang P, Qiao X, Yao Q, Yuan Z, Yao YG, Liu G, Zhang C, Liu L, Chen C.
J Neurosci. 2017 Oct 4;37(40):9741-9758
Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice.
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Neuropharmacology. 2017 Nov;126:200-212.
Conditioned place preference training prevents hippocampal depotentiation in an orexin-dependent manner.
Lu GL, Yau HJ, Chiou LC.
J Biomed Sci. 2017 Sep 6;24(1):69.
Gamma rhythm low field magnetic stimulation alleviates neuropathologic changes and rescues memory and cognitive impairments in a mouse model of Alzheimer’s disease.
Zhen J, Qian Y, Weng X, Su W, Zhang J, Cai L, Dong L, An H, Su R, Wang J, Zheng Y, Wang X.
Alzheimers Dement (N Y). 2017 Sep 11;3(4):487-497
Neural repair by NT3-chitosan via enhancement of endogenous neurogenesis after adult focal aspiration brain injury.
Hao P, Duan H, Hao F, Chen L, Sun M, Fan KS, Sun YE, Williams D, Yang Z, Li X.
Biomaterials. 2017 Sep;140:88-102.
Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice.
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Cell Rep. 2017 Aug 8;20(6):1360-1371.
Effects of M1 and M4 activation on excitatory synaptic transmisson in CA1.
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Hippocampus. 2017 Apr 19. doi: 10.1002/hipo.22732
Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis.
Cao N, Liao T, Liu J, Fan Z, Zeng Q, Zhou J, Pei H, Xi J, He L, Chen L, Nan X, Jia Y, Yue W, Pei X.
Cell Death Dis. 2017 Aug 10;8(8):e2996
Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
Huang H, Lin X, Liang Z, Zhao T, Du S, Loy MMT, Lai KO, Fu AKY, Ip NY.
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6992-E7001
Reduction of long-term potentiation at Schaffer collateral-CA1 synapses in the rat hippocampus at the acute stage of vestibular compensation.
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Korean J Physiol Pharmacol. 2017 Jul;21(4):423-428
Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.
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Caffeine Increases Hippocampal Sharp Waves in Vitro.
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Biol Pharm Bull. 2017;40(7):1111-1115
NETO1 Guides Development of Glutamatergic Connectivity in the Hippocampus by Regulating Axonal Kainate Receptors.
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Sci Rep. 2017 May 8;7(1):1521.
Memantine improves outcomes after repetitive traumatic brain injury.
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Behav Brain Res. 2017 Apr 12. pii: S0166-4328(17)30621-6. doi: 10.1016/j.bbr.2017.04.017
Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease.
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Nat Commun. 2017 Apr 3;8:14727. doi: 10.1038/ncomms1472
A maternal diet high in saturated fat impairs offspring hippocampal function in a sex-specific manner.
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Behav Brain Res. 2017 Mar 1;326:187-199. doi: 10.1016/j.bbr.2017.02.049.
Astrocyte lipid metabolism is critical for synapse development and function in vivo.
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Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory.
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A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization.
Stottmann RW, Driver A, Gutierrez A, Skelton MR, Muntifering M, Stepien C, Knudson L, Kofron M, Vorhees CV, Williams MT.
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ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion.
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Nat Commun. 2016 Dec 7;7:13770.
Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M Receptor Activation.
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Functional hyaluronate collagen scaffolds induce NSCs differentiation into functional neurons in repairing the traumatic brain injury.
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The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines.
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Dexmedetomidine promotes the recovery of the field excitatory postsynaptic potentials (fEPSPs) in rat hippocampal slices exposed to oxygen-glucose deprivation.
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Nat Commun. 2016 Jul 14;7:11935. doi: 10.1038/ncomms11935
Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling.
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Proc Natl Acad Sci U S A. 2016 Jun 13. pii: 201604519.
Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 × TgAD Mice.
Jin L, Gao LF, Sun DS, Wu H, Wang Q, Ke D, Lei H, Wang JZ, Liu GP.
Mol Neurobiol. 2016 Jun 21
与学习相关的突触可塑性减少和行为缺陷。大多数早期的研究聚焦在Fmr1基因敲除（KO）小鼠突触后长时程增强效应（LTP）。此次研究中，研究者们研究了FMRP在成年小鼠前扣带回(ACC)突触前LTP (pre-LTP)中的作用。在电压钳模式下的低频刺激可以诱导第II-III层椎体神经细胞的LTP。双脉冲比值是突触变化的一个重要参数，在低频刺激野生型小鼠后降低。在Fmr1 KO小鼠中pre-LTP消失。研究者同时使用了MED64平面多电极阵列记录EPSP场电位，他们发现当低频刺激和红藻氨酸受体抑制剂联
板的孔底，可以用传统微孔板处理装置来检测细胞因子。最近，每平方厘米包含上千个分子探针的大规模的微矩阵已研发出来，用于免疫检测一些蛋白。多点技术原来就可以点生物特异性的探针和样品于一固体支撑物上，使得可以在一个平面上而无需孔或管来分离样品进行多个免疫分析（即在多个样品中同时检测多个分析物）。 芯片实验室(Lab-On-A-Chip) 微流装置，通常也称之为芯片实验室或微分析系统，包括蚀刻在合适固体上的流体通道（它是用 于快速系列处理分析样品）。最近发展出了大量的CL微流体分析系统，它们有基于固定
适用于各种蛋白质和核酸的分析。商品化试剂盒的使用者只需增减探针交联微球和标记分子即可满足不同检测项目的需要。 [$page$] 3 液相芯片技术的应用进展 液相芯片是继平面芯片之后的一种新型芯片技术，是一种非常灵活的多元分析平台，在核酸、蛋白质等生物大分子的大规模分析中具有巨大的应用潜力，可用于免疫分析、核酸研究、酶学分析、受体配体识别分析等众多领域的研究，蛋白质蛋白质相互作用、蛋白质核酸相互作用分析等都可以在同一个平台上实现。鉴于液相芯片技术在高通量定性和定
