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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
PBT 2
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
747408-78-2
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1056.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥354.0 |
| 规格: | 5 mg | 产品价格: | ¥735.0 |
| 规格: | 10 mg | 产品价格: | ¥1073.0 |
| 规格: | 25 mg | 产品价格: | ¥1913.0 |
| 规格: | 50 mg | 产品价格: | ¥2838.0 |
| 规格: | 100 mg | 产品价格: | ¥4063.0 |
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PBT 1033
CAS No. : 747408-78-2
MCE 国际站:PBT 1033
产品活性:PBT 1033 (PBT 2) 是一种具有口服活性的铜/锌离子载体。PBT 1033 可恢复阿尔茨海默病 (AD) 小鼠模型中小鼠的认知能力。PB 1033 还对革兰氏阳性菌具有抗菌活性。
研究领域:Anti-infection
作用靶点:Bacterial
In Vitro: PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5 μM.
PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity.
PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons.
PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells.
PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates.
In Vivo: PBT 1033 (30 mg/kg/d, p.o., 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease.
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文献和实验Burnell pBT载体多克隆位点酶切:见附件 由于酶切位点离得近,用NotI 和 XhoI 是否能同时进行双酶切,还是需要分部酶切? 另外,分别含 NotI和XhoI酶切位点的修饰引物一般需要几个保护碱基? Burnell 期待各位朋友为我答疑解惑,最近实验很郁闷,很悲剧! angler5156 不知道你用的什么公司的酶进行酶切
Non-fluorescent protein/RNA double-labeling
% hydrogen peroxide in PBTH. This will produce a brown signal. Stop the reaction with several rinses of PBTH. In situ HYBRIDIZATION : 1. Fix the embryos for 20 minutes with 5% formaldehyde in PBT (PBT= filtered 1 X PBS with 0.1% Tween-20
Non-fluorescent protein/RNA double-labeling
of PBTH. In situ HYBRIDIZATION : 1. Fix the embryos for 20 minutes with 5% formaldehyde in PBT (PBT= filtered 1 X PBS with 0.1% Tween-20) at room temperature. 2. Wash 3 X 5 minutes with PBT. 3. Incubate the embryos with 50 ug/ml
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