Chemical phosphorylation amidi

运用肽库筛选磷酸化激酶motif方法 Screening Kinase Phosphorylation Motifs Using Peptide Libraries

  Screening Kinase Phosphorylation Motifs Using Peptide Libraries   Isaac A. Manke and Michael B. Yaffe Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA

Covalent Cross-Linking of Kinases with Their Corresponding Peptide Substrates

sites are present in mammalian proteome. To develop a global view of phosphorylation network, there is a need to map the connectivity between kinases and phosphoproteome. We developed a chemical kinase–substrate cross-linker 1 that converts transient

Discovery of Protein Kinase Phosphatase Inhibitors

Dynamic protein phosphorylation, a major cellular regulatory system, is tightly controlled by coordinating the reversible action of protein kinases and phosphatases. Recent evidence is consistent with sophisticated mechanisms that regulate