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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
-80°C
- 英文名：
RG-6321 (anti-VEGF)
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥2800.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥7200.0 |
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Ranibizumab (anti-VEGF)
CAS No. : 347396-82-1
MCE 国际站：Ranibizumab (anti-VEGF)
产品活性：Ranibizumab (RG-6321) (anti-VEGF) 是一种人源化的抗 VEGF 单克隆抗体片段，能够识别所有 VEGF-A 亚型 (VEGF110，VEGF121，以及 VEGF165)。动物模型中，Ranibizumab (anti-VEGF) 减缓视力丧失，并用于老年黄斑变性 (AMD) 的研究。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：VEGFR
In Vitro: Ranibizumab (RG-6321) is a humanized anti-VEGF monoclonal antibody fragment (IgG antigen-binding fragment (Fab-Y0317). Ranibizumab (0.0625-0.25 mg/ml; 72 hours) results in increased necrosis and apoptosis at in rat retinal cell cultures.
In Vivo: Studies in monkeys demonstrates that after a single intravitreal administration, Ranibizumab can distribute rapidly to the retina (6–24 h). Ranibizumab can rapidly penetrate through the retina to reach the choroid, just 1 h after intravitreal administration in rabbits.
In a study comparing the pharmacokinetics of 0.5 mg of intravitreal Ranibizumab with 1.25 mg of intravitreal Bevacizumab in the rabbit, the vitreous half-life of Ranibizumab is 2.88 days, shorter than the Bevacizumab half-life of 4.32 days. Peak concentrations in the aqueous humor of the treated eye at 3 days following treatment are 37.7 μg/ml for Bevacizumab and 17.9 μg/ml for Ranibizumab, respectively.
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文献和实验目的：克隆这个片断。 结果： 1, 5 TGTCTGGGTCTTGCACAATGACA 3 3 TCCGTTGTAGGTAGTATTTGGTC 5 rating L ength Tm GC% oD Ta opt sense 88 23 63.5 47.8 32.7 1 Anti-sense 100 23 60.8 43.5 33.6 1 product 82 406 88.2 49.0 55
This modification of qualitative ELISA (Enzyme-Linked Immunosorbent Assay) is used for either screening detection of anti-platelet antibodies or for detection of platelet-associated Ig (PAIg) (shown here). A. PROTOCOL 1. prepare platelets
OUTLINE This modification of qualitative ELISA (Enzyme-Linked Immunosorbent Assay) is used for either screening detection of anti-platelet antibodies or for detection of platelet-associated Ig (PAIg) (shown here). PROTOCOL
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