Powder: -20°C for 3 years In solvent: -80°C for 2 years
英文名:
MS 154
库存:
10
供应商:
TargetMol
CAS号:
2550393-21-8
规格:
5 mg
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产品名称:MS 154 产品别名:MS 154
产品介绍:MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib(Iressa). MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax> 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. Bioavailable in mice following ip administration. 纯度:N/A CAS:2550393-21-8
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