- ￥987 - 9320
- TargetMol
- 美国
- T40565
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
5MPN
- 库存：
10
- 供应商：
TargetMol
- CAS号：
47208-82-2
- 规格：
50 mg/25 mg/2 mg
| 规格： | 50 mg | 产品价格： | ￥9320.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥7170.0 |
| 规格： | 2 mg | 产品价格： | ￥987.0 |
Product Introduction
Bioactivity
英文名:5MPN
描述:5MPN is a novel compound that functions as a highly potent and selective inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4). This compound demonstrates oral activity and serves as a first-in-class inhibitor. Through competitive inhibition of the F6P binding site, 5MPN effectively hinders the functionality of PFKFB4, with a Ki value of 8.6 μM. Importantly, it exhibits no inhibitory effects on PFK-1 or PFKFB3. By specifically targeting the sugar metabolism of tumors, 5MPN exerts its anti-proliferative effects on various human cancer cell lines.
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文献和实验一、实验目的通过对好气性自生固氮菌的计数，了解稀释培养计数（MPN）的原理和方法。二、实验原理最大或然数（most probable number,MPN）计数又称稀释培养计数，适用于测定在一个混杂的微生物群落中虽不占优势，但却具有特殊生理功能的类群。其特点是利用待测微生物的特殊生理功能的选择性来摆脱其他微生物类群的干扰，并通过该生理功能的表现来判断该类群微生物的存在和丰度。本法特别适合于测定土壤微生物中的特定生理群（如氨化、硝化、纤维素分解、固氮、硫化和反硫化细菌等。见附表23-1）的数量
in different soils. An oxygenase gene (alkB ) codes for the initial step of the degradation of aliphatic alkanes under aerobic conditions. In this work, we present an MPN- and a real-time PCR method for the quantification of the bacterial gene alkB (coding
Myeloproliferative neoplasms (MPN) are clonal hematological malignancies that are frequently �associated with an acquired somatic mutation in JAK2 (JAK2V617F). Patients with MPN are at a high risk of developing thrombotic events. Endothelial
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