- ￥15000
- TargetMol
- 美国
- T39587
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
APJ receptor agonist 4
- 库存：
10
- 供应商：
TargetMol
- CAS号：
2135515-67-0
- 规格：
25 mg
Product Introduction
Bioactivity
英文名:APJ receptor agonist 4
描述:APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.
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文献和实验Elucidating Agonist-Selective Mechanisms of G Protein-Coupled Receptor Desensitization
to agonist-dependent regulation. In the case of the μ-opioid receptor (MOPr), we have shown that two agonists, morphine and the peptide agonist DAMGO, can induce MOPr desensitization by different mechanisms involving largely protein kinase C
PPAR/ Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma Cells
an important role in the effort to help extend its dismal 5-year survival rate (2 (PGE2 ), and the prostag-landin E2 receptor subtype, EP4, promote the growth and progression of human nonsmall cell lung carcinoma (NSCLC), the most common lung carcinoma
. These include receptormediated GDP release, GTP binding, and GTP hydrolysis. Fig. 1. Schematic diagram of receptor-mediated activation/mactivation cycle of G protein ( see Introduction for detailed comments). A, agonist; R
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