描述:Phomopsin A, a peptide mycotoxin originally derived from Phomopsis leptostromiformis, has been shown to be a potent microtubule inhibitor. Mechanistic studies suggest that the inhibition of polymerization of tubulin takes place via suppression of [3H]vinblastine binding to tubulin and enhancement of Colchicine to tubulin. More specific studies report that Phompsin A exerts its action on tubulin through interaction near the vinblastine binding site.