Rabbit anti-PPIA Polyclonal An

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抗体描述：

产品名称：Rabbit anti-PPIA Polyclonal Antibody

产品别名：PPIA抗体  

宿主：Rabbit

反应种属：Human;Mouse;Rat;Monkey

克隆性：Polyclonal Antibody

保存方法：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

产品描述：Cyclophilins are a highly conserved family of peptidylprolylcis-trans-isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA) (1,2). The complex of cyclophilin and CsA can bind to and inhibit calcineurin which leads to inhibition of the transcription factor NFAT and decreased production of cytokines (3,4). As isomerases, cyclophilins have been proposed to aid in protein folding. Cyclophilin A can bind to the p55 Gag protein of HIV and appears necessary for HIV infection (5,6). There is also some evidence that cyclophilins have nuclease activity and play a role in apoptosis (7).

用途范围： WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

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