Rabbit anti-CDCA8 Polyclonal A

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抗体描述：

产品名称：Rabbit anti-CDCA8 Polyclonal Antibody

产品别名：CDCA8抗体  

宿主：Rabbit

反应种属：Human;Mouse;Rat;Monkey

克隆性：Polyclonal Antibody

保存方法：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

产品描述：Borealin is a 280-amino acid protein that stabilizes the bipolar mitotic spindle. Borealin is part of a complex called Aurora B kinase that has essential regulatory roles at centromeres and the central spindle in cells undergoing mitosis. This complex makes up the enzymatic core of the chromosomal passenger complex (CPC). It is possible that the Borealin subunit directs the CPC to centromeric DNA. Deletion of Borealin delays mitotic progression and causes kinetochore-spindle to mis-attach. Deletion also causes an increase in bipolar spindles associated with ectopic asters. These extra poles, which form after chromosomes acquire their bipolar orientation, seriously disrupt chromosome allotment during anaphase. It is true that inappropriate chromosomal segregation and cell division may cause auneuploidy leading to cancer, so an abnormal expression of Borealin may lead to gastric cancer.

用途范围： WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

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