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- 技术资料
- 抗体名：
FASN抗体
- 抗体英文名：
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- 靶点：
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- 浓度：
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- 应用范围：
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- 宿主：
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- 适应物种：
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- 保质期：
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- 抗原来源：
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- 目录编号：
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- 级别：
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- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
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- 克隆性：
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- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
- 形态：
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- 亚型：
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- 免疫原：
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- 规格：
50ug/100ug
| 规格： | 50ug | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥2300.0 |
| 描述 | Fatty acid synthase (FASN) catalyzes the synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA. FASN is active as a homodimer with seven different catalytic activities and produces lipids in the liver for export to metabolically active tissues or storage in adipose tissue. In most other human tissues, FASN is minimally expressed since they rely on circulating fatty acids for new structural lipid synthesis (1).Recently, increased expression of FASN has emerged as a phenotype common to most human carcinomas. In breast cancer, immunohistochemical staining showed that the levels of FASN are directly related to the size of breast tumors (2). Studies also showed that FASN is highly expressed in lung and prostate cancers and that FASN expression is an indicator of poor prognosis in breast and prostate cancer (3-5). Furthermore, inhibition of FASN is selectively cytotoxic to human cancer cells (5). Thus, increased interest has focused on FASN as a potential target for the diagnosis and treatment of cancer as well as metabolic syndrome (6,7). |
| 别名 | FASN抗体;[Acyl-carrier-protein] S acetyltransferase, [Acyl-carrier-protein] S malonyltransferase, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-oxoacyl-[acyl-carrier-protein] synthase, Enoyl-[acyl-carrier-protein] reductase, FAS, FAS_HUMAN, FASN, Fatty acid synthase, MGC14367, MGC15706, OA 519, Oleoyl-[acyl-carrier-protein] hydrolase, SDR27X1, Short chain dehydrogenase/reductase family 27X member 1, |
| 宿主 | Rabbit |
| 特异性 | FASN Antibody detects endogenous levels of total FASN. |
| 反应种属 | Human;Mouse;Rat |
| 预测反应种属 | Bovine;Dog;Horse |
| 应用 | WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000 |
| 分子量 | Predicted molecular weight: 273kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 | A synthesized peptide derived from Human FASN(Accession P49327), corresponding to amino acid residues L26-L54. |
| 浓度 | 1mg/ml |
| 纯化方法 | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| 类型 | Polyclonal Antibody |
| 储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| 存储溶液 | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
| 背景说明 | Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. |
| 组织特异性 | Ubiquitous. Prominent expression in brain, lung, and liver. |
| 细胞定位 | Cytosol;Extracellular region or secreted;Golgi apparatus;Mitochondrion;Plasma Membrane; |
| UniProt | P49327 |
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文献和实验该产品被引用文献
- Short-Term Decreasing and Increasing Dietary BCAA Have Similar, but Not Identical Effects on Lipid and Glucose Metabolism in Lean MiceYuchen Sun, Bo Sun, Zhishen Wang, Yinfeng Lv, Qingquan Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023 Mar 11 .
影响因子： 6.208
- Lambda-cyhalothrin induces lipid accumulation in mouse liver is associated with AMPK inactivationDaqian Yang, Xiaotong Sun, Xiangjuan Wei, Boya Zhang, Xingpei Fan, Haining Du, Ruijiao Zhu, Yuri Oh, Ning Gu
FOOD AND CHEMICAL TOXICOLOGY. 2022 Dec 15 .
影响因子： 5.572
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Rabbit anti-FASN Polyclonal Antibody,FASN抗体
￥1500 - 2300
