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- 爱必信(absin)
- abs135537
- 上海
- 2025年07月12日
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- 详细信息
- 技术资料
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
- 规格：
100ug/50ug
| 规格： | 100ug | 产品价格： | ￥2300.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥1500.0 |
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抗体描述： 产品名称：Rabbit anti-BMI1 Polyclonal Antibody 产品别名：BMI1抗体 宿主：Rabbit 反应种属：Human;Mouse;Rat 克隆性：Polyclonal Antibody 保存方法：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles 产品描述：The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest (1-4). PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27. This histone methyl-transferase activity requires the Ezh2, Eed, and Suz12 subunits of the complex (5). Histone H3 methylation at Lys27 facilitates the recruitment of the second complex, PRC1, which ubiquitinylates histone H2A on Lys119 (6). Bmi1 is a component of the PRC1 complex, which together with Ring1 strongly enhances the E3 ubiquitin ligase activity of the Ring2 catalytic subunit (7). Bmi1 plays an important role in the regulation of cell proliferation and senescence through repression of the p16 INK4A and p19 ARF genes and is required for maintenance of adult hematopoietic and neural stem cells (3,4,8-10). 用途范围： WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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