公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抗体描述: 产品名称:Rabbit anti-ATR Polyclonal Antibody 产品别名:ATR抗体 宿主:Rabbit 反应种属:Human 克隆性:Polyclonal Antibody 保存方法:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles 产品描述:Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. 用途范围: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs133010 |
Rabbit anti-ATR Polyclonal Antibody |
50ug |
1500.00 |
立即咨询 |
abs133010 |
Rabbit anti-ATR Polyclonal Antibody |
100ug |
2300.00 |
立即咨询 |
产品更多信息请进入爱必信(absin)商城查看》》》
absin,您身边的科研百宝箱 专业提供试剂、耗材、仪器,在线订购,7*24h全国发货,方便快捷! |