描述 |
ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. |
别名 |
ACC1抗体;ACAC, ACACA, ACACA_HUMAN, ACACB, ACC alpha, ACC, ACC beta, ACC-alpha, ACC1, ACC2, ACCA, ACCB, Acetyl CoA carboxylase 1, Acetyl CoA carboxylase 2, Acetyl CoA carboxylase alpha, Acetyl CoA carboxylase beta, Acetyl Coenzyme A carboxylase alpha, Acetyl Coenzyme A carboxylase beta, Biotin carboxylase, COA1, COA2, HACC275, OTTHUMP00000164069, OTTHUMP00000164070, OTTHUMP00000164076, OTTHUMP00000240532, |
宿主 |
Rabbit |
特异性 |
Phospho-ACC1 (Ser80) Antibody detects endogenous levels of ACC1 only when phosphorylated at Serine 80. |
反应种属 |
Human;Mouse;Rat |
预测反应种属 |
Pig;Sheep;Dog;Bovine; |
应用 |
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
分子量 |
Predicted molecular weight: 266kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
免疫原 |
A synthesized peptide derived from Human ACACA(Accession Q13085), corresponding to amino acid residues S65-I94. |
浓度 |
1mg/ml |
纯化方法 |
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
类型 |
Polyclonal Antibody |
储存/保存方法 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
存储溶液 |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
背景说明 |
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. |
组织特异性 |
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. |
翻译后修饰 |
Phosphorylation on Ser-1263 is required for interaction with BRCA1. |
细胞定位 |
Cytoskeleton;Cytosol;Extracellular region or secreted;Mitochondrion;Nucleus; |
UniProt |
Q13085 |