描述:Polyglutamine Aggregation Inhibitor, PGL-137 is a cell-permeable benzothiazole compound that binds to polyglutamine (polyQ)-containing β-sheet structures and acts as a polyQ-aggregation inhibitor of Huntington's disease (HD). Polyglutamine Aggregation Inhibitor, PGL-137 has been shown to be non-toxic and prevent HDQ51 (flag-tagged HD exon 1 protein with 51 glutamines)-aggregation in 293 Tet-Off (293 tetracycline-off) cells with an IC50 of ~ 100 µM. Polyglutamine Aggregation Inhibitor, PGL-137 has also shown to be an inhibitor of Huntingtin.