保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
描述:MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 μM and a Ki of 1.4 μM.
溶解性:DMSO : 100 mg/mL (365.86 mM; Need ultrasonic)
体外研究:
MLS0315771 increases mannose flux toward glycosylation.MLS0315771 toxicity at higher concentrations is an off-target effect. MLS0315771 is toxic to the zebrafish embryos above 2 μM. At 8-10 μM, ~50% embryos appeare sick within 20 min, and most of them die by 30-60 min.