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- 爱必信(absin)
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- 2025年07月10日
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- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
387877-45-4
- 规格：
5mg
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抑制剂描述： 产品名称：MBC-11 trisodium salt 产品别名：见爱必信官网 英文别名：MBC-11 trisodium salt 靶点：Others CAS：387877-45-4 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： MBC-11 trisodium salt is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. Has potential to treat tumor-induced bone disease (TIBD). 溶解性：In Vitro: H2O : 125 mg/mL (216.58 mM; Need ultrasonic) 体外研究： MBC-11 shows similar activity profiles and significantly inhibits growth of all three cell lines between 10-8 and 10-4 M. MBC-11 decreases KAS-6/1 cell growth from approximately 56% at 10-8 M to 6% at 10-5 MCell Proliferation AssayCell Line:Human multiple myeloma cell lines (KAS-6/1, DP-6, KP-6).Concentration:Between 10-8 and 10-4 M.Incubation Time:48 hours.Result:Significantly inhibited multiple myeloma cell proliferation of each cell line at the majority of the tested concentrations. 体内研究：MBC-11 (0.04 μg/day, s.c.) has a lower incidence of bone metastases of 40% compared to those treated with PBS (90%) or 0.04 μg/day zoledronate (100%). MBC-11 also significantly decreases bone tumor burden compared to PBS- or zoledronate-treated mice. Weight gained in mice treated with up to 500 μg/day of MBC-11 is similar to the PBS treated group. These results demonstrate that MBC-11 decreases bone tumor burden, maintains bone structure, and may increase overall survival, warranting further investigation as a treatment for tumor-induced bone disease (TIBD).Animal Model:Approximately four-week old female Balb/c mice inoculated (s.c. injection into their mammary fatpads) with 500,000 4T1/luc cells at day 0 (breast tumor model).Dosage:0.04, 0.4, or 4.0 μg/day.Administration:S.C. daily from day 7 to 21.Result:47% of 17 mice treated with MBC-11 had detectable bone metastases.
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文献和实验疟原虫 Malaria Parasites(Plasmodium)
in one massGametocyte distorted by parasitecrescent or sausage shape; chromatin in a single mass (macrogametocyte) or diffuse (microgametocyte); dark pigment massP. vivax Ring normal to 11/4 X, round; occasionally fine Schüffner's dots; multiple infection
, several groups reported fluorescence enhancements on various silvered surfaces, including silver island films (SIFs) (7 , 8 ), deposited colloids (9 , 10 ), photodeposited structures (11 ), and electron beam-deposited nanostructures (12
Combined 3C-ChIP-Cloning (6C) Assay: A Tool to Unravel Protein-Mediated Genome Architecture
polymerase (REDTaq; Sigma D4309) (for polymerase chain reaction [PCR]; see Step 45 and Discussion) dNTP set (100 mM; Invitrogen) (for PCR; see Step 45 and Discussion) Ethanol (70% and 100%) Fetal bovine serum (10% in PBS) Formaldehyde
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