保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
描述:Hexa-D-arginine is an inhibitor of furin.
溶解性:
体外研究:
Hexa-D-arginine (10 μM) protects against the cytotoxic effects of anthrax toxin in RAW 264.7 cells. The concentrations of Hexa-D-arginine requires to block the cleavage of PA are similar to those required to inhibit toxicity.
体内研究:Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.