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- 爱必信(absin)
- 上海
- abs822518
- 2025年07月13日
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- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
65195-55-3
- 规格：
5mg
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抑制剂描述： 产品名称：Avermectin B1a 产品别名：见爱必信官网 英文别名：Avermectin B1a 靶点：Antiparasitic CAS：65195-55-3 纯度：95% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：Avermectin B1a is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis. 溶解性：DMSO : ≥ 100 mg/mL (114.54 mM) 体外研究： [3H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [3H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [3H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [3H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC50 values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations. 体内研究：Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD50) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms.
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文献和实验N -methyl-d -aspartate receptors (NMDARs) are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. Functional NMDARs are heterotetrameric assemblies of NR1 subunits with at least one type of NR2 subunits
Characterization of 5‐HT1A,B and 5‐HT2A,C Serotonin Receptor Binding
receptors. Neuropharmacol. 33:275‐317. Chamberlain, J., Offord, S.J., Wolfe, B.B., Tyau, L.S., Wang, H.L., and Frazer, A. 1993. Potency of 5‐hydroxytryptamine1a agonists
量（细胞干重），pH值 6．糖耗 总糖的测量：采用苯酚-硫酸比色法，以葡萄糖为标准品。 残糖含量：采用3、5一二硝基水杨酸比色法。 7．电镜、细胞膜通透性 8．活性氧(ROS) 9．质谱对比分析代谢物组变化 Enhanced production of avermectin B1a by medium optimization and glucose feeding with Streptomyces avermilitis Xu Zhinan
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