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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 英文名：
GT 949
- 库存：
13
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
460330-27-2
- 规格：
5mg
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抑制剂描述： 产品名称：GT 949 产品别名：见爱必信官网 英文别名：GT 949 靶点：EAAT2 CAS：460330-27-2 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM. 溶解性：DMSO : 50 mg/mL (94.76 mM; Need ultrasonic) 体外研究： GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3.GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%. 体内研究：
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文献和实验- Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell TerminalsFu-Sheng Tang, He-Lan Yuan, Jun-Bin Liu, Gong Zhang, Si-Yun Chen, Jiang-Bin Ke
eNeuro. 2022 May 17 ; 3
影响因子： 4.363
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