TD-106,2250288-69-6

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抑制剂描述：

产品名称：TD-106

产品别名：见爱必信官网

英文别名：TD-106

靶点：Others

CAS：2250288-69-6

纯度：98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.

溶解性：

体外研究：

TD-106 (0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM, 10 μM, and 100 μM; 72 hours) inhibits the proliferation of NCI-H929 myeloma cell line with an CC50 of 0.039 μM.TD-106 (1, 10, 100, and 1000 nM) induces the degradation of IKZF1/3 in NCI-H929 cells.Cell Cytotoxicity AssayCell Line:NCI-H929 cellsConcentration:72 hoursIncubation Time:0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM, 10 μM, and 100 μMResult:Inhibited cell proliferation with an CC50 of 0.039 μM.

体内研究：TD-106 (0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM, 10 μM, and 100 μM; 72 hours) inhibits the proliferation of NCI-H929 myeloma cell line with an CC50 of 0.039 μM.TD-106 (1, 10, 100, and 1000 nM) induces the degradation of IKZF1/3 in NCI-H929 cells.Cell Cytotoxicity AssayCell Line:NCI-H929 cellsConcentration:72 hoursIncubation Time:0.1 nM, 1 nM, 10 nM, 100 nM, 1000 nM, 10 μM, and 100 μMResult:Inhibited cell proliferation with an CC50 of 0.039 μM.

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