SGC-GAK-1,2226517-76-4

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抑制剂描述：

产品名称：SGC-GAK-1

产品别名：见爱必信官网

英文别名：SGC-GAK-1

靶点：GAK

CAS：2226517-76-4

纯度：98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK.

溶解性：DMSO ：78 mg/mL (200.39 mM)
Ethanol ：39 mg/mL (100.20 mM)

体外研究：

SGC-GAK-1 potently binds cyclin G-associated kinase (GAK), adaptor protein 2-associated kinase (AAK1), serine/threonine kinase 16 (STK16) with Kis of 3.1 nM, 53 µM, 51 µM, respectively.SGC-GAK-1 potently binds cyclin G-associated kinase (GAK), receptor-interacting protein kinase 2 (RIPK2), AarF domain containing kinase 3 (ADCK3), and nemo-like kinase (NLK) with KDs of 1.9 nM, 110 nM, 190 nM, and 520 nM, respectively.SGCGAK-1 (0.1, 1, and 10 µM, 48 hours or 72 hours) shows strong growth inhibition in LNCaP, VCaP, and 22Rv1 cells at 10 µM, but minimal effect in PC3 and DU145 cells.Cell Viability AssayCell Line:Prostate cancer cells (22Rv1, LNCaP, VCaP, PC3, DU145) Concentration:0.1, 1, and 10 µMIncubation Time:48 hours or 72 hoursResult:Showed potent antiproliferative activity in LNCaP and 22Rv1 cells with IC50s of 0.05±0.15 µM and 0.17±0.65 µM, respectively.

体内研究：

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