- ￥4631 - 17861
- 爱必信(absin)
- 上海
- abs821279
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
1835705-57-1
- 规格：
500mg/100mg
| 规格： | 500mg | 产品价格： | ￥17861.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥4631.0 |
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抑制剂描述： 产品名称：E3 ligase Ligand-Linker Conjugates 10 产品别名：见爱必信官网 英文别名：E3 ligase Ligand-Linker Conjugates 10 靶点：VHL/PROTAC CAS：1835705-57-1 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：E3 ligase Ligand-Linker Conjugates 10 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. 溶解性： 体外研究： E3 ligase Ligand-Linker Conjugates 10 uses the VHL ligand. The linker is 6-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 10 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase . 体内研究：E3 ligase Ligand-Linker Conjugates 10 uses the VHL ligand. The linker is 6-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 10 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase .
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文献和实验Chemistry of Minor Groove Binder–Oligonucleotide Conjugates
‐ODN structures. Structures of the MB, the ODN, and the linker all affect hybridization performance. MB‐ODN conjugates were prepared by treating an ODN containing a linking group with a suitable reactive group on the MB. The different linker structures
by fluorescent image analysis. Herein, we demonstrated that the method allows analysis of the intracellular protein stability as regulated by protein-degradation signals or an exogenously expressed E3 ubiquitin ligase.
I digestion to release the 3’ cDNA fragments from beads Resuspend the beads in +ligase or �ligase tubes by adding the following components. LoTE 85 ul 10x NEB buffer 4 10 ul 100x BSA 2 ul Asc I 2 ul Mix contents gently and well with pipette
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