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- 爱必信(absin)
- 上海
- abs821274
- 2025年07月13日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
1835283-94-7
- 规格：
10mg/5mg
| 规格： | 10mg | 产品价格： | ￥4550.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥2850.0 |
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抑制剂描述： 产品名称：Pan-RAS-IN-1 产品别名：见爱必信官网 英文别名：Pan-RAS-IN-1 靶点：Ras CAS：1835283-94-7 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors. 溶解性： 体外研究： Pan-RAS-IN-1 binds to KRasG12D-GppNHp with an affinity less than 20 μM. Pan-RAS-IN-1 binds to Ras proteins and exhibits lethality in cells partially dependent on expression of Ras proteins. The potency of pan-RAS-IN-1 correlates with the degree of dependency on the mutated isoform over a 5-fold concentration range. At some concentrations, pan-RAS-IN-1 is cytostatic, possibly due to pan-RAS inhibition. Pan-RAS-IN-1 is evaluated in primary T cell acute lymphoblastic leukemia (T-ALL) cells. Selective lethality is observed, with mutant NRAS cells retaining only 20%-40% viability after 5 μM treatment. 体内研究：Pan-RAS-IN-1 binds to KRasG12D-GppNHp with an affinity less than 20 μM. Pan-RAS-IN-1 binds to Ras proteins and exhibits lethality in cells partially dependent on expression of Ras proteins. The potency of pan-RAS-IN-1 correlates with the degree of dependency on the mutated isoform over a 5-fold concentration range. At some concentrations, pan-RAS-IN-1 is cytostatic, possibly due to pan-RAS inhibition. Pan-RAS-IN-1 is evaluated in primary T cell acute lymphoblastic leukemia (T-ALL) cells. Selective lethality is observed, with mutant NRAS cells retaining only 20%-40% viability after 5 μM treatment.
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文献和实验PNAS：RAS 抑制剂又添一员，新型蛋白模拟物或为癌症治疗
-Sos 复合体结构为合理设计稳定的 Ras 抑制剂提供了依据。来自纽约大学的 Paramjit S. Arora 团队在 PNAS 在线发表了题为 A Sos proteomimetic as a pan-Ras inhibitor [1] 的文章。该研究开发了一种结构稳定的 Sos 蛋白模拟物，可与野生型和致癌型 Ras 非共价结合，并调节下游激酶信号。该模拟物能够抵抗蛋白水解并进入癌细胞，对巨胞饮作用上调的癌细胞具有选择性毒性，包括那些具有致癌 Ras 突变的细胞，为开发 Ras 突变型癌症非
Panhandle PCR Approaches to Cloning MLL Genomic Breakpoint Junctions and Fusion Transcript Sequences
in leukemias with del(11)(q23), a normal karyotype, or trisomy 11, the latter two of which sometimes are associated with partial tandem duplications of MLL itself (Proc Natl Acad Sci USA 97:2814–2819, 2000; Proc Natl Acad Sci USA 94:3899–3902, 1997
CGAAACG-3′ product size 80bp 非甲基化引物 上游为5′- TTTGTG TTTTGATGTTTGTAGGTTTTTGT-3′ 下游为5′- AACTCCA CACTC TTCCAAAAACAAAACA-3′ product size 94bp 参考：Tae Jun Park, Sang-Uk Han, Yong-Kwan Cho,et al. Methylation of O6- Methylguanine-DNA Methyltransferase Gene
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