- ￥1985 - 5094
- 爱必信(absin)
- 上海
- abs821040
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
1627856-64-7
- 规格：
5mg/1mg
| 规格： | 5mg | 产品价格： | ￥5094.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥1985.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：GSK3179106 产品别名：见爱必信官网 英文别名：GSK3179106 靶点：RET CAS：1627856-64-7 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：GSK3179106 is a potent and selective RET kinase inhibitor with an IC50 of 0.4 nM. 溶解性： 体外研究： GSK3179106 (10 nM-100 µM; 8 days for TT cells, 3 days for SK-N-AS and A549 cells) inhibits the proliferation of the RET-dependent TT cell line with a mean IC50 value of 25.5 nM however has no effect on the proliferation of the RET-independent SK-NAS and A549 cell lines (mean IC50>10 µM and IC30>17 µM, respectively).GSK3179106 inhibits RET phosphorylation in SK-N-AS cells and TT cells with mean IC50s of 4.6 nM and 11.1 nM, respectively.Cell Viability AssayCell Line:TT, SK-N-AS and A549 cellsConcentration:10 nM-100 µMIncubation Time:8 days for TT cells, 3 days for SK-N-AS and A549 cellsResult:Inhibited the proliferation of TT cell line with a mean IC50 value of 25.5 nM however had no effect on the proliferation of the SK-NAS and A549 cell lines (mean IC50>10 µM and IC30>17 µM, respectively). 体内研究：GSK3179106 (10 nM-100 µM; 8 days for TT cells, 3 days for SK-N-AS and A549 cells) inhibits the proliferation of the RET-dependent TT cell line with a mean IC50 value of 25.5 nM however has no effect on the proliferation of the RET-independent SK-NAS and A549 cell lines (mean IC50>10 µM and IC30>17 µM, respectively).GSK3179106 inhibits RET phosphorylation in SK-N-AS cells and TT cells with mean IC50s of 4.6 nM and 11.1 nM, respectively.Cell Viability AssayCell Line:TT, SK-N-AS and A549 cellsConcentration:10 nM-100 µMIncubation Time:8 days for TT cells, 3 days for SK-N-AS and A549 cellsResult:Inhibited the proliferation of TT cell line with a mean IC50 value of 25.5 nM however had no effect on the proliferation of the SK-NAS and A549 cell lines (mean IC50>10 µM and IC30>17 µM, respectively).
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