YK11,1370003-76-1

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抑制剂描述：

产品名称：YK11

产品别名：见爱必信官网

英文别名：YK11

靶点：Androgen Receptor

CAS：1370003-76-1

纯度：98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：YK11 is a partial agonist of androgen receptor, with osteogenic activity.

溶解性：DMSO : ≥ 64 mg/mL (148.65 mM)

体外研究：

YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100 nM or 500 nM). YK11 (0.5 µM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5 µM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 µM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling.

体内研究：

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