KHS 101,1262770-73-9

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

抑制剂描述：

产品名称：KHS 101

产品别名：见爱必信官网

英文别名：KHS 101

靶点：Others

CAS：1262770-73-9

纯度：98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.

溶解性：DMSO : 15 mg/mL
Ethanol : 15 mg/mL

体外研究：

KHS101 increased neuronal differentiation of adherently cultured rat NPCs in a dose-dependent fashion (EC50 ∼ 1 μM). KHS101-induced neuron formation (40–60% TuJ1+ cells at 1.5–5 μM KHS101) was also observed under neurosphere-forming conditions in secondary neurospheres derived from both the hippocampus and the subventricular zone (SVZ) of adult rats . SMMC-7721 and SK-Hep-1 cells were cultured with different KHS101 concentrations (40 μM and 20 μM, respectively) to determine the IC50 values. The number and size of spheres were significantly decreased after treatment with KHS101 compared with the control (DMSO) treatment. Sphere formation was dependent on the KHS101 concentration. Bmi1, c-Myc, and Nanog were all decreased in the presence of KHS101. Compared with the control (DMSO), KHS101 decreases the expression of p-AKT, p-GSK3β and β-catenin, as well as the expression of the downstream markers c-Myc and cyclin D1 .

体内研究：The doses of 6 mg/kg KHS101 (i.v. and s.c.) resulted in reasonable plasma concentrations (>1.5 μM) with a plasma half-life of 1.1–1.4 h, and relative bioavailability of 69% following s.c. dosing. Most importantly, the distribution of KHS101 to the brain was extensive as demonstrated by a brain-to-plasma AUC(0–3h) ratio of ∼8 (dosing: 3 mg/kg KHS101, i.v.) .

产品信息订购：

产品更多信息请进入爱必信(absin)商城查看》》》

absin，您身边的科研百宝箱
专业提供试剂、耗材、仪器，在线订购，7*24h全国发货，方便快捷！