- ￥1150 - 5750
- 爱必信(absin)
- 上海
- abs820437
- 2025年07月16日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
125079-83-6
- 规格：
50mg/5mg
| 规格： | 50mg | 产品价格： | ￥5750.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥1150.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：CU-CPT-8m 产品别名：见爱必信官网 英文别名：CU-CPT-8m 靶点：TLR CAS：125079-83-6 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM. 溶解性：DMSO : 30 mg/mL (118.92 mM; Need ultrasonic) 体外研究： CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67±10 nM and negligible cytotoxicity. The Kd value of CU-CPT-8m is determined to be 220 nM. CU-CPT-8m only reduces the proinflammatory response in the TLR8-overexpressing cells strongly supports that CU-CPT-8m directly recognizes TLR8 in cells. It is particularly notable that TLR7 signaling is not affected at concentrations up to 75 μM. TLR7 and TLR8 are closely related and share many common ligands. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC50 of 90±10 nM, which is in good agreement with its IC50 value determined in HEK-Blue TLR8 cells. 体内研究：
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