- ￥683 - 2048
- 爱必信(absin)
- 上海
- abs819758
- 2025年07月08日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
346692-04-4
- 规格：
50mg/10mg
| 规格： | 50mg | 产品价格： | ￥2048.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥683.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：DC260126 产品别名：见爱必信官网 英文别名：DC260126 靶点： CAS：346692-04-4 纯度：≥98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：DC260126, a small-molecule antagonist of GPR40. 溶解性：DMSO : ≥ 100 mg/mL (325.33 mM) 体外研究： 体内研究：DC260126 is a small-molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice. After giving different dose of DC260126 to nine-week-old db/db mice for 5 days, the fasting serum insulin (FSI) level is decreased dose-dependently. And both 10 mg/kg and 30 mg/kg body weight can reduce FSI level of db/db mice significantly. DC260126, a small-molecule antagonist of GPR40, is evaluated the effect of on glucose and lipid metabolism in obese Zucker rats. Rats are treated intraperitoneally with 6 mg/kg of DC260126 for 8 weeks. DC260126 treatment significantly decreases serum insulin levels by about 20% (147.5±10.42 versus 182.36±7.22, p<0.05). DC260126 treatment causes an elevation of body weight gain from 3 to 6 weeks compared with the vehicle-treated group. Compared with the vehicle-treated group, DC260126 treatment induces a significant increase of Akt phosphorylation levels in liver as assessed by western blotting.
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