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- 爱必信(absin)
- 上海
- abs819581
- 2025年07月14日
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- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
36913-39-0
- 规格：
100mg
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抑制剂描述： 产品名称：MPP+ iodide 产品别名：见爱必信官网 英文别名：MPP+ iodide 靶点：Others CAS：36913-39-0 纯度：≥98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： MPP+ iodide is a metabolite of dopaminergic neurotoxin MPTP which stimulates the production of the superoxide radical resulting in apoptosis in PC12 cells. Studies suggest that MPP+ iodide is a selective inhibitor of mitochondrial complex I and it decreases mitochondrial REDOX activity. In addition, GSK-3β is a mediator of MPP+ iodide induced neurotoxicity. Alternate studies indicate that the D-loop of human mtDNA is destabilized by MPP+ iodide via releasing the nascent H-strands of mtDNA. 溶解性：DMSO : 100 mg/mL (336.54 mM; Need ultrasonic) 体外研究： MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity. 体内研究：
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文献和实验Nature: 全球首个！单细胞测序绘制人胚胎造血和免疫系统发育图谱
在人类胚胎早期发育中，造血首先发生在卵黄囊（着床后的 2 - 3 周）；之后，在胚胎内的 aorta-gonad-mesonephros (AGM) 区产生造血祖细胞；然后，卵黄囊和 AGM 区的祖细胞在肝脏等胎儿组织器官中定植，直到妊娠中期，肝脏仍是造血的主要器官。尽管造血发育在脊椎动物中存在保守性，但老鼠和人类之间还是存在明显的区别。因此，通过对人体早期胚胎组织进行全面的研究，可以解析早期造血的分子和细胞结构，为了解免疫缺陷、儿童白血病和贫血症提供了基础数据，并可加深对 HSC/MPP
In Vivo Microdialysis to Study Striatal Dopaminergic Neurodegeneration
/1-methyl-4-phenilpyridinium ion (MPTP/MPP+ ), either given systemically or locally applied into the nigrostriatal pathway, to resemble PD features in animals. Both neurotoxins selectively and rapidly destroy catecholaminergic neurons
on dopamine neuron differentiation and viability. This cell model can be used to study the effects of siRNA-induced gene knockdown, either alone or in combination with PD-related cellular stressors such as MPP+ , and is compatible with high-throughput cellular
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