- ￥992 - 8159
- 爱必信(absin)
- 上海
- abs819500
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 英文名：
SU5408; VEGFR2 Kinase Inhibitor I
- 库存：
12
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
15966-93-5
- 规格：
10mg/1mg
| 规格： | 10mg | 产品价格： | ￥8159.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥992.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：SU5408 产品别名：见爱必信官网 英文别名：SU5408 靶点：VEGFR CAS：15966-93-5 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： SU5408 is a highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. VEGFR2 Kinase Inhibitor I has been shown to not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 > 100 μM). 溶解性：DMSO : 6 mg/mL (19.33 mM; Need ultrasonic and warming) 体外研究： 3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 is found to be the most potent and selective VEGFR2 inhibitor among the compounds. SU5408 shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50>100 µM). 体内研究：
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