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- 爱必信(absin)
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- abs818756
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
304462-19-9
- 规格：
5mg/2mg
| 规格： | 5mg | 产品价格： | ￥4101.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥2734.0 |
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抑制剂描述： 产品名称：AVE 0991 产品别名：见爱必信官网 英文别名：AVE 0991 靶点：Angiotensin Receptor CAS：304462-19-9 纯度： 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM. 溶解性：DMSO 体外研究： AVE 0991 is a nonpeptide compound that evokes effects similar to Ang-(1-7) on the endothelium. AVE 0991 and unlabeled Ang-(1-7) compete for high-affinity binding of -Ang-(1-7) to bovine aortic endothelial cell membranes with IC50s of 21±35 and 220±280 nM, respectively. Peak concentrations of NO and O2- release by AVE 0991 sodium salt and Ang-(1-7) (both 10 μM) are not significantly different (NO: 295±20 and 270±25 nM; O2-: 18±2 and 20±4 nM). However, the released amount of bioactive NO is ≈5 times higher for AVE 0991 in comparison to Ang-(1-7). 体内研究：AVE 0991 (0.58 nmol/g) produces a significant decrease of water diuresis in WT mice compared with vehicle-treated animals (0.06±0.03 mL versus 0.27±0.05; n=9 for each group; P2O versus 681.1±165.8 mOsm/KgH2O in vehicle-treated mice; PMas abolishes the antidiuretic effect of AVE 0991 during water loading (0.37±0.10 mL versus 0.27±0.03 mL in AVE 0991-treated mice). As observed with C57BL/6 mice, administration of AVE 0991 (0.58 nmol/g) in water-loaded Swiss mice also produces a significant decrease of the urinary volume compared with vehicle-treated animals (0.13±0.05 mL versus 0.51±0.04 mL ; P. One week of treatment with AVE-0991 produces a significant decrease in perfusion pressure (56.55±0.86 vs. 68.73±0.69 mmHg in vehicle-treated rats) and an increase in systolic tension (11.40±0.05 vs. 9.84±0.15 g in vehicle-treated rats), rate of tension rise (+dT/dt; 184.30±0.50 vs. 155.20±1.97 g/s in vehicle-treated rats), rate of tension fall (−dT/dt; 179.60±1.39 vs. 150.80±2.42 g/s in vehicle-treated rats). A slight increase in heart rate (HR) is also observed (220.40±0.71 vs. 214.20±0.74 beats/min in vehicle-treated rats.
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文献和实验细胞名称的由来。NK 细胞的数量相对于 B 细胞和T细胞来讲非常稀少，但是 NK 细胞具有非常强烈的细胞毒作用（Cytotoxicity），在机体的天然免疫中占据非常重要的地位。 T 细胞主要分泌一些免疫效应分子（如IFN-γ、IL-4、IL-10、IL-17、IL-21等）或者直接对感染或异化的免疫细胞进行杀伤，CD3 是 T 细胞的主要表面标志物；B 细胞是抗体的来源细胞，激活后大量产生抗体的 B 细胞特称为浆细胞，是机体生产抗体的工厂，其常用的表面标志物为 CD19。在流式检测中，我们通常用 CD
Curators Jingyang Chen, Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA, 98109, USA. jingyang.chen@sbri.org Anyone should feel free to add themselves as a curator for this consensus protocol
Hard Agar Medium for Egg Collection Plates
. We buy 100 lb. barrels (~$1,295) from Moorhead & Co., Inc., 6923 Woodley Ave., Van Nuys, CA 91406. Corn Syrup We use Karo® light corn syrup (about $8.40 per gallon through our campus food services).
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