保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
描述:
垂体腺苷酸环化酶激活多肽受体(PAC)1拮抗剂。
溶解性:Water :100 mg/mL (24.85 mM)
体外研究:
PACAP 6-38 blocks the CARTp-induced phosphorylation of ERK in differentiated cells.
体内研究:Intravesical administration of the PAC1 receptor antagonist, PACAP(6-38) (300 nM), significantly (p ≤ 0.01) increases intercontraction interval (2.0-fold) and void volume (2.5-fold) in NGF-OE mice. PACAP(6-38) has no effects on bladder function in WT mice. Intravesical administration of PACAP(6–38) (300 nM) significantly (p ≤ 0.01) reduces pelvic sensitivity in NGF-OE mice but is without effect in WT mice.