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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
- 库存:
99
- 供应商:
爱必信(上海)生物科技有限公司
- CAS号:
142880-36-2
- 规格:
50mg/2mg/10mg/5mg
| 规格: | 50mg | 产品价格: | ¥5603.0 |
|---|---|---|---|
| 规格: | 2mg | 产品价格: | ¥778.0 |
| 规格: | 10mg | 产品价格: | ¥1839.0 |
| 规格: | 5mg | 产品价格: | ¥1192.0 |
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抑制剂描述: 产品名称:GM6001 产品别名:见爱必信官网 英文别名:GM6001 靶点:MMP CAS:142880-36-2 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: GM6001 (galardin, ilomastat)是泛MMP抑制剂,对MMP-1,MMP-2,MMP-3,MMP-7,MMP-8,MMP-9,MMP-12,MMP-14和MMP-26的Ki为0.4-27 nM。 溶解性:DMSO : 38.9 mg/mL (100 mM) 体外研究: GM6001 inhibits human skin fibroblast collagenase with Ki of 0.4 nM when assayed with a synthetic thio ester substrate at pH 6.5, with 50-fold selectivity over two bacterial enzymes, thermolysin and Pseudomonas aeruginosa elastase. GM 6001 (0.1 nM - 10 nM) inhibits gelatinase A and gelatinase B produced by T-cells, thus inhibits T-cell homing. 体内研究:Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates.
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文献和实验, GM)被认为是对IA早期诊断的间接真菌学标准。GM抗原检测目前常用的方法是ELISA,市场上已有的商业化产品有 Bio-Rad 公司的曲霉菌抗原检测试剂盒(PlateliaTMAspergillus Ag)。该采用酶联免疫双抗体夹心法,特异性检测血清中的半乳甘露聚糖(Galactomannan, GM)抗原,不仅可以帮助临床实现IA的早期诊断,较临床症状出现提早6天,较临床确诊提早10天。2 还能保证实验结果高度的准确性,灵敏度和特异性分别为92.1% 和97.5%。3
) + 0.5% non-fat dry milk (0.25 gm) + 1% SDS (0.5 gm) + 8% dextran sulfate (4 gm, Sigma D-6001) 42°C shaking water bath
Analysis of Hematopoietic Phenotypes in Knockout Mouse Models
of the hematopoietic system, surrogate stem, and progenitor cell assays (34 –36 ), and the level of expression of hematopoietic lineage antigens during lymphoid (33 ), myeloid, and erythroid cell maturation and differentiation. Abbreviations: LTRA-stem cells
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