- ￥419 - 982
- 爱必信(absin)
- 上海
- abs817904
- 2025年07月09日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 保质期：
-
- 英文名：
-
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
51298-62-5
- 规格：
500mg/100mg
| 规格： | 500mg | 产品价格： | ￥982.0 |
|---|---|---|---|
| 规格： | 100mg | 产品价格： | ￥419.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：L-NAME HCl 产品别名：见爱必信官网 英文别名：L-NAME HCl 靶点：NOS CAS：51298-62-5 纯度：≥98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： L-NAME盐酸盐是一种细胞渗透性的NO合成酶抑制剂, 作用于nNOS (牛), eNOS (人), 和 iNOS (鼠)时, Ki值分别为 15 nM, 39 nM, 和 4.4 μM。 溶解性：DMSO : 27 mg/mL (100 mM) 体外研究： L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity, with Nw-nitro-L-arginine methyl ester (L-NAME) being at the head. Freshly dissolved L-NAME is a 50 fold less potent inhibitor of purified brain NOS (mean IC50= 70 μM) than L-NOARG (IC50= 1.4 μM), but the apparent inhibitory potency of L-NAME approached that of L-NOARG upon prolonged incubation at neutral or alkaline pH. HPLC analyses reveal that NOS inhibition by L-NAME closely correlated with hydrolysis of the drug to L-NOARG. 体内研究：L-NAME infusion significantly decreases NKT-leukocyte level, tumor-necrosis factor (TNF)-alpha production by T-splenocytes and macrophages, and interferon-gamma production by T-leukocytes, monocytes, and T-splenocytes, as well as increased interleukin-6 production by T-leukocytes and monocytes and nitrate/nitrite production by T-leukocytes. There is increasing evidence that nitric oxide may be involved in learning and memory. l-NAME produces a task-dependent impairment of fear extinction, and implies that nitric oxide signaling is involved in memory process of certain fear extinction tasks. Chronic L-NAME administration induces cardiac hypertrophy in rodent models. Six weeks L-NAME administration induces significant cardiac hypertrophy compared to control hearts.
产品信息订购：
absin，您身边的科研百宝箱 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验【求助】使用eNOS的抑制剂L-NAME后对eNOS的磷酸化有影响吗？
cwqq2003 请问大家使用eNOS的抑制剂L-NAME后对eNOS的磷酸化有影响吗？ freecell 以前的研究结果： http://www.actaps.com.cn/qikan/cpaper/zhaiyao.asp?bsid=599454 jempoo Circulation. 2002 Mar 26;105(12):1497-502.
In vitro transcription reaction
) 26 mL ,, mix, spin incubate at 37 oC for 15 min. Start: End: End the reaction by adding: 7 ml 10X STE (0.2 M Tris-HCl, pH 7.5; 1 M NaCl; 0.1 M EDTA) 38 ml DDW Mix by pipeting --Spot 1 ml on paper disk inside a scintillation bottle. --Purify
In vitro transcription reaction
1(free from Rnase -10 U/ml; BMB) 26 mL ,, mix, spin incubate at 37 oC for 15 min. Start: End: End the reaction by adding: 7 ml 10X STE (0.2 M Tris-HCl, pH 7.5; 1 M NaCl; 0.1 M EDTA) 38 ml DDW Mix by pipeting --Spot 1 ml on paper disk
技术资料