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- 爱必信(absin)
- 上海
- abs817731
- 2025年07月15日
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![(1S,3R,4aS,7S,8S,8aS)-8-{2-[(2R,4R)-4-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-6-氧代四氢-2H-吡喃-2-基]乙基}-4A-羟基-3,7-二甲基-1,2,3,4,4A,7,8,8A-八氢-1-萘基2,2-二甲基丁N酸酯,125142-16-7](https://img1.dxycdn.com/2022/1125/060/7615201498534394853-14.jpg!wh200)
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 英文名：
ENMD-2076 L-(+)-Tartaric acid
- 库存：
11
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
1291074-87-7
- 规格：
25mg/10mg/5mg/2mg
| 规格： | 25mg | 产品价格： | ￥1189.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥874.0 |
| 规格： | 5mg | 产品价格： | ￥607.0 |
| 规格： | 2mg | 产品价格： | ￥419.0 |
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抑制剂描述： 产品名称：ENMD-2076 L-(+)-Tartaric acid 产品别名：见爱必信官网 英文别名：ENMD-2076 L-(+)-Tartaric acid 靶点：Aurora Kinase;VEGFR;PDGFR;FGFR;FLT3;Src CAS：1291074-87-7 纯度：98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：ENMD-2076 L-(+)-Tartaric acid is the tartaric acid of ENMD-2076, selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold more selective for Aurora A than Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2. 溶解性：DMSO:100 mg/mL warmed (190.27 mM) 体外研究： ENMD-2076 indicates activity against multiple kinases involved in angiogenesis, including FLT3, RET, FLT4/VEGFR3, SRC, NTRK1, CSF1R/FMS, LCK, VEGFR2/KDR, FGFR1/2, and PDGFRα with IC50 from 1.86-120 nM. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025-0.7 μM, which induces apoptosis and G2/M phase arrest. ENMD-2076 induces regression or complete inhibition of tumor growth in tumor xenograft models derived from breast, colon, melanoma, leukemia, and multiple myeloma cell lines. ENMD-2076 is the L (+) tartrate salt of ENMD-981693. ENMD-2076 shows significant cytotoxicity against myeloma cell lines (IM9, ARH-77, U266, RPMI 8226, MM.1S, MM.1R, NCI-H929) and primary cells with IC50 from 2.99 to 7.06 μM, which induces apoptosis. ENMD-2076 indicates low cytotoxicity to haematopoietic progenitors. ENMD-2076 inhibits the phosphoinositide 3-kinase/Akt pathway and downregulates survivin and X-linked inhibitor of apoptosis. ENMD-2076 also inhibits aurora A and B kinases, and induces G2/M cell cycle arrest. 体内研究：ENMD-2076 has sustained inhibitory effects on the activation of Flt3 as well as VEGFR2/KDR and FGFR1/2 in HT29 xenograft model. ENMD-2076 could prevent the formation of new blood vessels and regress formed vessels in MDA-MB-231 xenograft model. Oral treatment with ENMD-2076 (50, 100, 200 mg/kg per day) inhibits the tumour growth in H929 human plasmacytoma xenografts, with significant reduction in phospho-Histone 3 (pH3), Ki-67, and angiogenesis, and also a significant increase in cleaved caspase-3.
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文献和实验，两法一致。此法与其他肠杆菌及非O157大肠杆菌无交叉反应。深部真菌感染的诊断极为困难，因自血液或体液中培养的阳性率很低。以敏感方法检查此类菌的可溶性抗原则可快速诊断，如念珠菌菌体成分中含D-阿拉伯醇和L-阿拉伯醇，自血液或体液中直接检出此种抗原，可迅速诊断深部念珠菌病。Mitsutake等比较了自39名深部念珠菌病患者血液中检出抗原的四种方法。应用斑点印迹法检查其弹力酶（Enolase）抗原的阳性率71.8%，特异性100% 。应用Latex凝集法（Cand-Tec试剂）检查热敏抗原阳性率76
Metabolic labeling Immunoprecipitation
Purpose and backgrounds About nuclide... 35-S Decay: (b-ray,0.167 MeV) Half life: 87.5 days Thick acrylic shield can block most of the emission.Because of the low energy,it is impossible to detect spillage/contamination by usual
Metabolic labeling Immunoprecipitation
Purpose and backgrounds About nuclide... 35-S Decay: (b-ray, 0.167 MeV) Half life: 87.5 days Thick acrylic shield can block most of the emission. Because of the low energy, it is impossible to detect spillage
