- ￥1339 - 4444
- 爱必信(absin)
- 上海
- abs817590
- 2025年07月14日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
714971-09-2
- 规格：
25mg/10mg/5mg
| 规格： | 25mg | 产品价格： | ￥4444.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥2647.0 |
| 规格： | 5mg | 产品价格： | ￥1339.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：BMS 599626 产品别名：见爱必信官网 英文别名：BMS 599626 靶点：EGFR CAS：714971-09-2 纯度：＞98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1. 溶解性：Ethanol ：16 mg/mL (30.2 mM) 体外研究： BMS-599626 also inhibits the related receptor HER4, but with reduced potency with IC50 of 190 nM. BMS-599626 is identified as an ATP-competitive inhibitor for HER1 and as an ATP-noncompetitive inhibitor for HER2 with Ki of 2 nM and 5 nM, respectively. BMS-599626 inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2, including Sal2, BT474, N87, KPL-4, HCC202, HCC1954, HCC1419, AU565, ZR-75-30, MDA-MB-175, GEO, and PC9 cells with IC50 of 0.24 μM, 0.31 μM, 0.45 μM, 0.38μM, 0.94 μM, 0.34 μM, 0.75 μM, 0.63 μM, 0.51 μM, 0.84 μM, 0.90 μM and 0.34 μM, respectively. While the proliferation of the ovarian tumor cell line A2780 and MRC5 fibroblasts, neither of which expresses HER1 or HER2, are not inhibited significant by BMS-599626. A recent study shows that BMS-599626 significantly enhances the radiosensitivity of HN-5 cells expressing both EGFR and Her2 cell, by promoting cycle redistribution and inhibiting DNA repair. 体内研究：In vivo, oral administration of BMS-599626 results in a dose-dependent inhibition of Sal2 tumor growth at doses ranging from 60 mg/kg to 240 mg/kg, yielding a potent antitumor activity in a human breast tumor KPL-4 xenograft at its maximum tolerated dose of 180 mg/kg, and also has similar antitumor activity in other HER2 amplified xenograft models, as well as other HER1-overexpressing xenograft models.
产品信息订购：
absin，您身边的科研百宝箱 |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验药 Keytruda（MSD）获 FDA 批准，三个月后，Opdivo （BMS）获 FDA 批准（Opdivo 也将成为首个在中国大陆上市的 PD-1 单抗药）。2016 年 FDA 批准首个抗 PD-L1 的抗体药 Tecentrip（Roche）应用于肿瘤治疗（图 1）。图 1：PD-1/PD-L1 发展历程中的部分关键节点PD-1/PD-L1 工作机制是怎样的？PD-1/PD-L1 免疫检查点抑制剂在癌症研究中倍受瞩目，而恶性肿瘤的十大重要标志之一就是免疫检查点参与的免疫逃避。PD-1 与其配体 PD
Immunohistochemical Assays of Farnesyltransferase Inhibition in Patient Samples
time, three different FT inhibitors (FTIs), SCH66336, R115777, and BMS-214662, are undergoing clinical testing. Phase III studies with R115777 in pancreatic and colorectal cancer have completed accrual. Because the FTIs are among the first potential
Combined Chromatin Immunoprecipitation and Bisulfite Methylation Sequencing Analysis
immunoprecipitation (ChIP) with bisulfite methylation sequencing assays, so-called ChIP and bisulfite methylation sequencing (ChIP-BMS). This technique provides precise information of DNA methylation status at the selected DNA fragments precipitated by the antibodies
技术资料暂无技术资料 索取技术资料
