- ￥289 - 687
- 爱必信(absin)
- 上海
- abs817348
- 2025年07月11日
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- 详细信息
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 英文名：
NSC165960；SC2964；IBMX；Isobutylmethylxanthine
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
28822-58-4
- 规格：
100mg/25mg
| 规格： | 100mg | 产品价格： | ￥687.0 |
|---|---|---|---|
| 规格： | 25mg | 产品价格： | ￥289.0 |
| 产品描述 | |
| 描述 | IBMX is a potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 3-异丁基-1-甲基黄嘌呤; NSC165960；SC2964；IBMX；Isobutylmethylxanthine |
| 外观 | off-white powder |
| 可溶性/溶解性 | DMSO : 50 mg/mL (224.98 mM; Need ultrasonic) Ethanol : ≥ 7.14 mg/mL (32.13 mM) |
| 生物活性 | |
| 靶点 | Phosphodiesterase (PDE) |
| In vitro(体外研究) | At 100 μM, KMUP-1 (a xanthine derivative) and IBMX are the most effective at inducing tracheal relaxation; the magnitude of the relaxation responses induced by KMUP-1 and IBMX are not significantly different. IBMX (100 μM) activates renal outer medullary K+ (ROMK) channels (n=6, P+ (HK)-fed rats with IBMX (100 μM) for 20 min leads to a significant increase in tubular cAMP content to 1.43±0.35 pg/mm tubule length (n=14) compare with that measured in vehicle-treated controls (0.61±0.13 pg/mm tubule length, n=12, P. |
| In vivo(体内研究) | IBMX, a non-selective PDE inhibitor significantly decreases the liver glycogen storage (mg/g, IBMX 22±1.5 P0.05) also mc2 does not change plasma glucose (control=141±3 and mc2=145±5). IBMX has the highest efficacy on increasing plasma glucose. Treatments with IBMX and Apocynin significantly decrease cold-induced elevation of right ventricular (RV) systolic pressure (23.5±1.8 and 24.2±0.6 mmHg, respectively) although they do not decrease RV pressure to the warm control levels. IBMX or Apocynin significantly reduces medial layer thickness (19.0±0.9, and 16.9±0.8 μm, respectively) and increases lumen diameter (62.7±4.2, and 59.5±4.3 μm, respectively) of small PAs in cold-exposed rats. |
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3-异丁基-1-甲基黄嘌呤,IBMX,28822-58-4
￥289 - 687
