Citicoline sodium salt,33818-1

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抑制剂描述：

产品名称：Citicoline sodium salt

产品别名：见爱必信官网

英文别名：Citicoline sodium salt

靶点：Endogenous Metabolite

CAS：33818-15-4

纯度：＞98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine. It also serves as a choline donor in the biosynthesis of the neurotransmitter acetylcholine. Citicholine demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Exogenous administration of citicoline to rodents (500 mg/kg i.p. immediately after ischemia and at 3-h reperfusion) has been shown to stimulate the synthesis of phosphatidylcholine, sphingomyelin, and cardiolipin and to attenuate the release of arachidonic acid and the accumulation of ceramide.

溶解性：Water : 100 mg/mL

体外研究：

Citicoline, is an essential component of cell membrane phospholipids. Citicoline (CDP-choline or cytidinediphosphate choline; cytidine 5′-diphosphocholine) is a complex organic molecule composed of ribose, pyrophosphate, cytosine and choline. Citicoline is very water soluble and has a bioavailability of greater than 90%. Citicoline presented no mitogenic and chemotactic effects on hCMEC/D3; however, it significantly increased wound recovery, spheroid sprouting and strongly induced endothelial tube-like structure formation in Matrigel. Citicoline induced the expression of phospho-extracellular-signal regulated kinase (ERK)-1/2. It protects hCMEC/D3 against cell damage/apoptosis. Citicoline induces angiogenesis and improves survival of human brain microvessel endothelial cells through pathways involving p-ERK1/2, and IRS-1.

体内研究：Citicoline increases nerve cell membrane phospholipids and reduces free fatty acid accumulation. citicoline could reverse the neurologic deficits in a rat model of temporary ischemia with reperfusion. The compound is quickly catabolized, and the products arising are subsequently available for diverse biosynthetic pathways and ultimately excreted as carbon dioxide. The lack of acute and chronic toxicity of citicoline has been repeatedly confirmed in rodents and dogs. citicoline may protect the ischemic neurons by providing a negative effect on the activation of the caspase apoptotic pathway. citicoline has vascular protective, and pro-angiogenic effects.

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