公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抑制剂描述: 产品名称:MCB-613 产品别名:见爱必信官网 英文别名:MCB-613 靶点:Src CAS:1162656-22-5 纯度: 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:MCB-613 is a potent steroid receptor coactivator (<b>SRC</b>) stimulator. 溶解性:体外: DMSO 60mg/mLwarming(197.11mM) Ethanol 60mg/mLwarming(197.11mM) Water <1mg/mL
4%DMSO+30%PEG300+ddH2O 2mg/mL 体外研究: MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). 体内研究:In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. 产品信息订购:
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