公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抑制剂描述: 产品名称:Omaveloxolone (RTA-408) 产品别名:见爱必信官网 英文别名:Omaveloxolone (RTA-408) 靶点:Nrf2 CAS:1474034-05-3 纯度:99.64 % 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor <b>Nrf2</b> and inhibits NF-κB signaling. Phase 2. 溶解性:体外: DMSO 100mg/mL(180.27mM) Ethanol 20mg/mL(36.05mM) Water <1mg/mL
10%DMSO+90%Cornoil 30mg/mL 体外研究: RTA 408 potently increases expression of Nrf2 target genes and reverses IFNγ-mediated suppression of Gclc expression in RAW 264.7 cells. In a panel of eight human tumor cell lines, RTA 408 inhibits growth with an average GI50 value of 260 nM and induces apoptosis. RTA 408 also inhibits NF-κB and activates JNK in tumor cells. 体内研究:In mice with radiation-induced dermatitis, 1.0% RTA 408 markedly reduces epidermal and collagen thickening, prevents dermal necrosis and completely alleviates skin ulcers. In rat skin, RTA 408 activates Nrf2 and induces cytoprotective genes. RTA 408 also mitigates hematopoietic acute radiation syndrome in mice. 产品信息订购:
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