Levothyroxine sodium,55-03-8

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抑制剂描述：

产品名称：Levothyroxine sodium

产品别名：见爱必信官网

英文别名：Levothyroxine sodium

靶点：Others

CAS：55-03-8

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

Levothyroxine is the major hormone derived from the thyroid gland. It is the agonist of Thyroid hormone receptor alpha and beta.

溶解性：DMSO ：100 mg/mL (125.18 mM)

体外研究：

Levothyroxine can upregulate the expression of P-gp mRNA and protein in LS180 cells and can produce the same effect in Caco-2 cells, which are relatively lacking in PXR. It doea not affect the expression of CYP3A4 in either cell line.

体内研究：Levothyroxine is a synthetic T4 hormone that is biochemically and physiologically indistinguishable from the natural one, and it is administered when the body is deficient in the natural hormone. Its nain site of absorption is small intestine, more specifically through the duodenum, jejunum and ileum. Very little is absorbed in the stomach. The bioavailability is about 70-80 % in euthyroid person and may be slightly higher in hyperthyroid patients. The absorption of levothyroxine appears to be influenced by gastric pH. Tmax=2-3 hours and the half-time T1/2 is 6.2 and 7.5 days in euthyroid and hypothyroid patients, respectively. T4 hormones is known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. T4-treatment induces a dose-dependent increase in the duration of contractions. Abnormal uterine contractile pattern are induced by T4-treatment.

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