公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抑制剂描述: 产品名称:Ro3280 产品别名:见爱必信官网 英文别名:Ro3280 靶点:PLK CAS:1062243-51-9 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: Ro3280是一种有效的,高选择性Polo-like kinase 1(PLK1)抑制剂,IC50为3 nM。RO3280强烈抑制肺癌细胞株H82,大肠癌细胞HT-29,乳腺癌细胞MDA-MB-468,前列腺癌细胞PC3和皮肤癌细胞A375增殖,IC50为分别5 nM,10 nM,19 nM,12 nM和70 nM。 溶解性:Ethanol :27.2 mg/mL (50 mM) DMSO :27.2 mg/mL (50 mM) 体外研究: RO3280 shows the strong anti-proliferative activity against lung cancer cell line H82, colorectal cancer cell HT-29, breast cancer cell MDA-MB-468, prostate cancer cell PC3 and skin cancer cell A375 with IC50s of 5, 10, 19, 12 and 70 nM, respectively. 体内研究:RO3280 displays robust antitumor activity in nude mouse implanted with HT-29 human colorectal tumors ranging from 72% tumor growth inhibition when dosed once weekly at 40 mg/kg, to complete tumor regression when dosed more frequently.. 产品信息订购:
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