A-205804,251992-66-2

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抑制剂描述：

产品名称：A-205804

产品别名：见爱必信官网

英文别名：A-205804

靶点：Integrin

CAS：251992-66-2

纯度：>98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

A-205804强有效和选择性的抑制E-selectin和ICAM-1的表达， IC50分别为20 nM和25 nM。A-205804选择性抑制人内皮细胞中细胞粘附分子ICAM-1和E- selectin的表面表达。A-205804抑制IL-1β诱导的E-selectin表达 (IC50 = 20 nM) 和ICAM-1表达 (IC50 = 10 nM)，对TNFα诱导的表达抑制效果差不多。A-205804 抑制PMA诱导的 E-selectin 表达的效率明显降低(IC50 > 1000 nM), 原因尚不清楚，但是but A-205804 是强有效的ICAM-1表达抑制剂 (IC50 = 40 nM) 。

溶解性：Ethanol ：3 mg/mL (10 mM)
DMSO ：30 mg/mL (100 mM)

体外研究：

A-205804 selectively inhibits the surface expression of the cell adhesion molecules ICAM-1 and E-selectin in human endothelial cells. A-205804 inhibites the IL-1β-induced expression of E-selectin (IC50 = 20 nM) and ICAM-1 (IC50 = 10 nM) with essentially the same level of potency as that for TNFα-induced expression. For reasons which are unclear, the ability of A-205804 to inhibit PMA-induced E-selectin expression is significantly reduced (IC50 > 1000 nM), but A-205804 is a potent inhibitor of ICAM-1 expression (IC50 = 40 nM) using this protein-kinase C-activating agent.

体内研究：

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