公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抑制剂描述: 产品名称:Ozanimod 产品别名:见爱必信官网 英文别名:Ozanimod 靶点:LPL Receptor CAS:1306760-87-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator. Phase 3. 溶解性:Ethanol :10 mg/mL (24.72 mM) DMSO :75 mg/mL (185.4 mM) 体外研究: In S1P1R-HEK293T cells, Ozanimod induces sustained S1P1R internalization and degradation. 体内研究:In vivo, Ozanimod shows high oral bioavailability and volume of distribution. In a MOG-induced EAE mouse model, Ozanimod (3 mg/kg, p.o.) suppresses clinical symptoms. In a rat TNBS model of inflammatory bowel disease, Ozanimod (1.2 mg/kg, p.o.) inhibits clinical and histological disease scores. In a Naïve CD4+CD45Rbhi T cell adoptive transfer model, Ozanimod (1.2 mg/kg, p.o.) also significantly reduced disease severity as assessed by measuring the degree of inflammation, gland loss, hyperplasia, neutrophil infiltrate and mucosal thickness. 产品信息订购:
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