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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
83730-53-4
- 规格：
1g/500mg/200mg/50mg
| 规格： | 1g | 产品价格： | ￥5821.0 |
|---|---|---|---|
| 规格： | 500mg | 产品价格： | ￥2613.0 |
| 规格： | 200mg | 产品价格： | ￥1676.0 |
| 规格： | 50mg | 产品价格： | ￥728.0 |
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抑制剂描述： 产品名称：L-Buthionine-(S,R)-Sulfoximine 产品别名：见爱必信官网 英文别名：L-Buthionine-(S,R)-Sulfoximine 靶点：Others CAS：83730-53-4 纯度：≥97% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述： L-Buthionine-(S,R)-Sulfoximine is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of L-Buthionine-(S,R)-Sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, L-Buthionine-(S,R)-Sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors. 溶解性：H2O : 41.67 mg/mL (187.44 mM; Need ultrasonic) 体外研究： L-Buthionine-(S,R)-sulfoximine (BSO: 50 μM) treatment for 48 hr results in a 95% decrease in ZAZ and M14 melanoma cell line GSH levels, and a 60% decrease in GST enzyme activity. GST-π protein and mRNA levels are significantly reduced in both cell lines. L-Buthionine-(S,R)-sulfoximine (BSO) induces oxidative stress in a cell by irreversibly inhibiting g-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione (GSH). 体内研究：The average number of eye-spots (mean±SEM) is 5.36±0.29 (n=46), 7.79±0.45 (n=34) and 8.78±0.61 (n=32) in untreated controls, 2 mM L-Buthionine-(S,R)-sulfoximine (BSO) and 20 mM BSO treated mice, respectively. The 2 mM BSO treatment results in ~30% more eye-spots, and the 20 mM treatment results in 40% more eye-spots compared with untreated mice. It is showed that BSO causes an elevated frequency of DNA deletions during mouse development. BSO treatment reduced GSH concentration in mouse fetuses by 55% and 70% at 2 mM and 20 mM BSO doses, respectively, compared to untreated mice. Co-treatment with 2 mM BSO and 20 mM NAC depleted GSH to a similar extent as 2 mM BSO, consistent with the function of BSO to inhibit the g-GCS enzyme indispensable for GSH synthesis. Like GSH, cysteine levels dropped following BSO treatment.
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文献和实验细菌菌落从光滑（ smooth）的膨滑状态转变为粗糙而皱缩的状态，称前者为 S型，后者为 R型。几乎对所有的寄生细菌，当将其从动物体中分离转入人工培养基中培养，尤其是移在液体培养基中进行连续培养时，往往会看到这种现象。这种变化和其他方面的各种重要变化具有很密切的关系。首先，细菌表面的物质结构发生变化，且相互连结，结果在培养液中容易凝聚而沉淀。例如在肠道细菌细胞壁上的聚脂多糖的 O抗原侧链消失并 R核裸露出来时，便转变为 R型。因此有关 R核合成的基因群中任何一个基因发生
亦称刺激-反应理论。是把学习作为某种刺激（ S： stimulus）与某种反应（ R： response）的结合来考虑的学习理论。其代表人物是赫尔（ C． L． Hull），他的理论体系蒐集于 1943年的“ Principleof Behavior”一书中。其源流可追溯到英国的联合主义心理学， 1898年由桑代克（ E． L． Thorndike）提倡的效应定律，而开始出现了学习是刺激与反应的结合的主张。提倡行为主义心理学的沃森（ J． B． Wat－ son）采用了桑代克的这个主张
S-Adenosyl-L-Homocysteine Hydrolase
The enzymatic activity that catalyzes the reversible hydrolysis of S-adenosyl-L -homocysteine (AdoHcy) to L -homocysteine (Hey) and adenosine (Ado), or, in reverse, the formation of AdoHcy from Hcy and Ado, is known as AdoHcy hydrolase (AHH
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