保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
描述:
RVX-208 is a potent BET bromodomain inhibitor with IC50 of 0.510 ??M for BD2, about 170-fold selectivity over BD1.
溶解性:DMSO : 69 mg/mL (186.3 mM)
体外研究:
As a BET bromodomain inhibitor, RVX-208 preferentially binds to the second bromodomain found on BET proteins. RVX-208, as a stimulator of apolipoprotein (APO) AI gene expression, increases apoA-I and HDL-C in vitro.
体内研究:RVX-208 significantly increases serum apoA-I and HDL-C in AGMs, and enhances cholesterol efflux via different pathways.