公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抑制剂描述: 产品名称:INT-747(Obeticholic acid) 产品别名:见爱必信官网 英文别名:INT-747(Obeticholic acid) 靶点:FXR CAS:459789-99-2 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述: INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity. 溶解性:DMSO:84 mg/mL (199.7 mM) Ethanol:84 mg/mL warmed (199.7 mM)
体外研究: In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM. 体内研究:In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. Obeticholic Acid (p.o.) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension. 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs810675 |
INT-747(Obeticholic acid) |
10mg |
1036.00 |
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abs810675 |
INT-747(Obeticholic acid) |
100mg |
5160.00 |
立即咨询 |
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