公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 试剂描述: 产品名称:(5S,6Z,8E,10E,12R,14Z)-5,12-二羟基-N-(2-羟基乙基)-6,8,10,14-二十碳四烯酰胺 产品别名: CAS号:877459-63-7 英文别名:(5S,6Z,8E,10E,12R,14Z)-5,12-二羟基-N-(2-羟基乙基)-6,8,10,14-二十碳四烯酰胺 分子量:379.5 分子式:C22H37NO4 纯度:≥97% 外观:见爱必信官网 保存方法:Store at -20℃ 描述:The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2.1,2 LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM.3 LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1. 应用: 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs47046174 |
(5S,6Z,8E,10E,12R,14Z)-5,12-二羟基-N-(2-羟基乙基)-6,8,10,14-二十碳四烯酰胺 |
100ug |
13034.00 |
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