Syk Inhibitor II,726695-51-8

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产品名称：Syk Inhibitor II

产品别名：Spleen Tyrosine Kinase Inhibitor II;

CAS号：726695-51-8

英文别名：Syk Inhibitor II

分子量：340.3

分子式：C₁₄H₁₅F₃N₆O

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20℃

描述：Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC₅₀ = 41 nM) in an ATP-competitive manner.¹ It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC₅₀s = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively).¹ Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC₅₀ = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID₅₀ = 13.2 mg/kg, s.c.).¹

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